1、1Greater Phoenix:An Emerging Bioscience HubThis report focuses on a cluster of industries including medical device and medical technology manufacturing,clinical and translational research,biotechnology,genomics,and pharmaceutical manufacturing,among others.The Greater Phoenix region has adopted the

2、term“bioscience”to refer to this cluster.CBRE uses the term“l(fā)ife science.”They are used interchangeably in this report.Copyright 2024 All rights reserved.Information contained herein,including projections,has been obtained from sources believed to be reliable,but has not been verified for accuracy o

3、r completeness.CBRE,Inc.makes no guarantee,warranty or representation about it.Any reliance on such information is solely at your own risk.This information is exclusively for use by CBRE clients and professionals and may not be reproduced without the prior written permission of CBREs Global Chief Ec

4、onomist.Executive SummaryGreater Phoenix Bioscience RootsLocal Innovation Regional DemographicsIndustries,Employment,&Specialized WorkforceEducation&Talent PipelineEmerging Bioscience CorridorsPhoenix Bioscience CoreOperating CostsInnovation Funding&Capital TrendsRegional Healthcare Assets&Clinical

5、TrialsT able of Contents011505212725031711233921Greater Phoenix:An Emerging Bioscience HubGreater Phoenixs dedication to fostering innovation,research and development(R&D),collaboration,and expansion in the bioscience sector continues to draw companies in the industry to the metro.The markets succes

6、s in this field is largely due to low barriers of entry,a growing population and an entrepreneurial ethos.By continuing to utilize its distinct advantages,Greater Phoenix aims to realize a grand vision of becoming a global front-runner in the bioscience industry.NATION-LEADING GROWTH By almost any r

7、elevant metricjob and talent supply increases,new business formation,specialized educational pipelines,competitive federal research dollars,or risk capital allocationGreater Phoenix has been a leading bioscience and life science growth market over the past decade.TALENT AND EDUCATION Startups and es

8、tablished bioscience firms alike find Greater Phoenix a desirable place to be.More than 26,000 bioscience employees*are in the region,in addition to the well over 261,000 related jobs in healthcare.Companies in the industry can leverage the growing and talented workforce fueled by the states three p

9、ublic research universitiesArizona State University,University of Arizona and Northern Arizona Universityas well as an extensive community college system.Arizona educational institutions offer programs with an emphasis in biomedical sciences,precision medicine and health professions,providing a dive

10、rse demographic of students the opportunity to participate in groundbreaking research,leading-edge patient care and innovative solutions.BUSINESS CULTURE The regions business-friendly culture fosters an entrepreneurial spirit,showcased by the fact that over the last decade,Greater Phoenix added new

11、bioscience and life science business locations at a 1.3 times higher rate than the nation.State and local governments support emerging technologies and pioneering policies,allowing businesses to thrive.Early initiatives such as AZAdvances and the Arizona Health Innovation Trust Fund aim to support t

12、he creation of jobs,economic growth and the development of scientific discovery,which can become life-enhancing treatments and possible life-saving cures.*The term bioscience employees reflects CBREs definition of bioscience/life science industries.431943 Vitalant(formerly known as Blood Systems Inc

13、.)1962 Barrow Neurological Institute1965 The National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK),an institute within the National Institutes of Health(NIH)1973 Medtronic(formerly known as Micro-Rel)1987 Mayo Clinic Hospital 1943-19872001 Proposition 301 goes into effect,which est

14、ablishes the Technology&Research Initiative Fund to provide funding to Arizona public universities for technology and research-based initiatives.2002 Public and private investors partner to fund the creation of the Translational Genomics Research Institute(TGen),which conducts cutting-edge research

15、on the genetic components of diseases.TGen is the initial spark that enables much subsequent bioscience development in the Greater Phoenix region,including the establishment of the Phoenix Bioscience Core(PBC).Local philanthropic grantmaking organization the Flinn Foundation commissions Arizonas Bio

16、science Roadmap,a long-term strategic plan,“with the goal of Arizona becoming globally competitive and a national leader in select areas of the biosciences by 2025.”The Flinn Foundation disseminates regular updates and sophisticated reporting on the Roadmap to this day.The City of Phoenix establishe

17、s the Phoenix Biomedical Campus,later renamed the Phoenix Bioscience Core(PBC),on 30 acres in downtown Phoenix.In the coming decades,it will serve as the regions nexus of research,education,and innovation in the fields of medicine and biosciences.2020 Exact Sciences2021 850 PBC,a 7-floor,227,000 squ

18、are foot lab-enabled center“for life science companies to grow and be a part of the Phoenix bio-ecosystem,”opens its doors in the PBC.2022 The University of Arizona reveals plans for its Center for Advanced Molecular and Immunological Therapies(CAMI),“a hub for precision medicine research,innovation

19、 and education”that will be located in the PBC.CAMI will operate out of a 7-story,200,000 square foot building that will house as many as 40 research groups in GMP-compliant labs.2023 Arizona State University announces it will open its headquarters for ASU Health in downtown Phoenix,the centerpiece

20、of which will be the ASU School of Medicine and Advanced Medical Engineering.The NIDDK will relocate its Phoenix operations to the 850 PBC building.NIDDK also has its genomics lab on the PBC campus.Mayo Clinic submits its zoning application to the City of Phoenix for the Discovery Oasis,an addition

21、to its campus in north Phoenix that will encompass“advanced research and development,medical equipment manufacturing,outpatient treatment facilities and associated tenant amenities within 3.3 million square feet.”The Phoenix Medical Quarter in midtown Phoenix is designated as a bioscience research h

22、ub by Plaza Companies,the citys third such designated area.2004 Molecular Profiling Institute(TGen and International Genetics Consortium(IGC)spinoff;acquired by Caris Life Sciences)2005 GE Healthcare Regenesis Biomedical2006 Banner Alzheimers Institute2007 W.L.Gore&Associates The University of Arizo

23、na College of Medicine Phoenix launches its four-year medical education program.2008 Cancer Treatment Centers of America(acquired by City of Hope)2010 Celgene(acquired by Bristol Meyers Squibb)2001-20022004-20102016 TGen joins City of Hope.Dexcom2017 Becton Dickinson G.T.Medical Technologies CND Lif

24、e Sciences The University of Arizona establishes 245,000 square feet of research space at the Biomedical Sciences Partnership Building in the PBC.2019 Bristol Myers Squibb acquires local pharmaceutical manufacturer Celgene for$74B.The WearTech Applied Research Center is established in midtown Phoeni

25、x.To date,the WearTech Center has helped 22 companies in the wearables/weartech space advance toward commercialization by securing matching funds from the Arizona Commerce Authority.BD Peripheral Intervention2016-20192020-20222023Greater Phoenix Bioscience RootsGreater Phoenixs history as a bioscien

26、ce and life sciences market extends back to the middle of the 20th century.One of the most pivotal years in that history was in 2002,when collaboration across public,private,and nonprofit sectors led to the founding of the Translational Genomics Research Institute(TGen)as well as the Flinn Foundatio

27、ns“Arizonas Bioscience Roadmap.”Since then,with continued cross-sector collaboration,the region has risen in prominence as a hub of business creation and attraction,world-class healthcare facilities,talent development and translational closed-loop clinical research in bioscience and the life science

28、s.ANNOUNCEMENTS&MARKET ENTRANCESBioscience Companies in Greater PhoenixSource:Maricopa Association of Governments.1,750 EMPLOYEESHQ IN SAN DIEGO,CA1,100 EMPLOYEESHQ IN DUBLIN,IRELAND1,380 EMPLOYEESHQ IN W.WHITELAND TOWNSHIP,PA 690 EMPLOYEESHQ IN DALLAS/FT.WORTH,TX1,300 EMPLOYEESHQ IN NEWARK,DE80 EMP

29、LOYEESHQ IN SCOTTSDALE,AZMesaTempePhoenixTempe&ScottsdalePhoenix&TempePhoenix&TempeScottsdale&Phoenix280 EMPLOYEESHQ IN ABBOT PARK,ILScottsdale&Casa Grande200 EMPLOYEESHQ IN CHICAGO,ILPhoenix265 EMPLOYEESHQ IN KALAMAZOO,MIChandler,Phoenix&Tempe100 EMPLOYEESHQ IN BETHESDA,MD Phoenix25 EMPLOYEESHQ IN

30、PHOENIX,AZPhoenix&Tempe350 EMPLOYEESHQ IN PHOENIX,AZPhoenix95 EMPLOYEESHQ IN TEMPE,AZTempe&Phoenix50 EMPLOYEESHQ IN TEMPE,AZTempe20 EMPLOYEESHQ IN SCOTTSDALE,AZScottsdale56320 EMPLOYEESHQ IN NEW YORK,NY600 EMPLOYEESHQ IN SCOTTSDALE,AZScottsdaleRegional Presence3,200 EMPLOYEESHQ IN PHOENIX,AZRegional

31、 Presence1,000 EMPLOYEESHQ IN BURLINGTON,NC150 EMPLOYEESHQ IN TEMPE,AZTempe140 EMPLOYEESHQ IN DUBLIN,OHTolleson&Chandler8Company SpotlightsSource:Maricopa Association of Governments&Company Websites.7Dexcom designs,develops and commercializes continuous glucose monitoring(CGM)systems used by people

32、with diabetes and healthcare providers in the hospital.The companys major products include integrated Dexcom G6 CGM system,Dexcom Share remote monitoring system,Dexcom Real-Time API,Dexcom ONE CGM system,associated software and mobile apps.It provides Dexcom Care training to users of CGM system and

33、other support services.The company offers products to endocrinologists,physicians,diabetes educators and others.W.L.Gore&Associates is a global materials science company spanning five continents and thousands of products across industries.The company develops products for medical implants;fabric lam

34、inates;and cable,filtration,membrane,venting,fiber technologies,and sealant for diverse industries through its proprietary technologies with the polymer polytetrafluoroethylene(PTFE).Gore caters to aerospace,automotive,chemical processing,computer,telecommunications,electronics,energy,environmental,

35、industrial,manufacturing,military and pharmaceutical,biotechnology,and textile markets.LOCATED TO MESA IN 20161,750 GREATER PHOENIX EMPLOYEESLOCATED TO PHOENIX IN 20071,300 GREATER PHOENIX EMPLOYEESLabcorp is a global leader of innovative and comprehensive laboratory services offering general and sp

36、ecialty laboratory testing,bone marrow and human leukocyte antigen(HLA)testing,clinical trials services,drug testing services,deoxyribonucleic acid(DNA)identification services,forensic identity services,insurance health plan services,paternity testing services,patient services,personalized medicine,

37、and hospital services that help doctors,hospitals,pharmaceutical companies,researchers and patients make clear and confident decisions.They provide insights and advance science to improve health and improve lives through unparalleled diagnostics and drug development laboratory capabilities.LONGSTAND

38、ING PRESENCE IN GREATER PHOENIX1,000 GREATER PHOENIX EMPLOYEESConfluent Medical Technologies applies materials science to MedTech innovation.The company specializes in the expert design,development,and large-scale manufacturing of interventional catheter-based devices and implants.Their key capabili

39、ties include Nitinol components and tubing,balloon and complex catheters,high-precision polymer tubing,and implantable textiles,thereby helping patients with advanced technological care for better recovery.Confluent operates in eight state-of-the-art facilities across the United States and Costa Ric

40、a and currently employs over 2,000 employees throughout the entire company.The corporate headquarters is located at the Forum in Scottsdale,AZ.FOUNDED IN SCOTTSDALE IN 1991600 GREATER PHOENIX EMPLOYEESTranslational Genomics Research Institute(TGen)is an Arizona-based non-profit organization that pro

41、vides groundbreaking research that leads to life changing results.They educate,train and inspire the next generation of researchers and physicians and increase the publics understanding of genomics.Their research focuses on common and complex diseases,including cancer,neurological disorders,infectio

42、us diseases,and rare childhood illnesses.The company officially launched in 2002,occupying interim office space provided by Arizona Public Service,while Banner Health System,in partnership with Quest Diagnostics,donated temporary lab space.In March 2005,TGen moved into its state-of-the-art headquart

43、ers at the Phoenix Biomedical Core in Downtown Phoenix,AZ.TGen joined cancer treatment and research center City of Hope in 2016.FOUNDED IN PHOENIX IN 2002350 GREATER PHOENIX EMPLOYEESCaris Life Sciences specializes in pathology,molecular profiling,and microvesicle technology for the diagnosis and tr

44、eatment of cancerous tissues.With a primary focus on cancer,Caris has built a market-leading portfolio of precision medicine tools that have helped more than half a million cancer patients worldwide.Caris patient impact,as well as molecular knowledge of disease,has significantly vaulted the field of

45、 Oncology from an empiric medicine methodology to a precision medicine approach.Caris has also begun research and development activities for cardiovascular disease and is actively building a multi-omic database to fuel the next-generation suite of precision medicine solutions for cardiovascular heal

46、th.Caris is a spinoff of TGen and the IGC.It was originally called the Molecular Profiling Institute.LOCATED TO PHOENIX IN 2004690 GREATER PHOENIX EMPLOYEES109The Phoenix Epidemiology and Clinical Research Branch of the National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK),an insti

47、tute of the National Institutes of Health(NIH),will occupy CLIA-certified lab space on the seventh floor of the PBCs 850 PBC building starting in 2025.To execute its mission of determining the etiology of type 2 diabetes mellitus and obesity,the NIDDKs Phoenix branch will perform metabolic research

48、with a focus on diabetes and nutrition as an intramural program,in addition to overnight stay studies with human participants using state-of-the-art metabolic chambers.The NIDDK will also maintain its genomics research lab on the PBC campus.GE Healthcare is a provider of transformational medical tec

49、hnologies and services.It specializes in medical imaging,information technologies,medical diagnostics,patient monitoring systems,drug discovery,biopharmaceutical manufacturing technologies,computerized data management,performance improvement,medical equipment and performance services.CND Life Scienc

50、es is a developer of a medical diagnostic platform designed to detect key pathological markers in the peripheral nervous system that had been previously out of reach.The companys platform detects,visualizes,and quantifies the presence of abnormal,phosphorylated alpha-synuclein in cutaneous nerve fib

51、er and confirmation of synucleinopathy in patients with suspected Parkinsons disease(PD),enabling medical experts with a convenient,accurate,minimally invasive alternative to aid in the diagnosis of neurodegenerative diseases.LOCATED TO PHOENIX IN 1965 AND 2025 EXPANSION PLANNED100 GREATER PHOENIX E

52、MPLOYEESLOCATED TO PHOENIX IN 2005200 GREATER PHOENIX EMPLOYEESFOUNDED IN SCOTTSDALE IN 201720 GREATER PHOENIX EMPLOYEESCranial Technologies has been the worlds leading non-surgical treatment provider for plagiocephaly(flat head syndrome)for over 35 years.The company offers a remodeling device and 6

53、-ounce devices which are custom-made,lightweight and made of hypoallergenic materials that ensure safety and comfort,thereby helping parents to reshape their babys head by capturing their brain growth.To date,they have cared for over 300,000 babies using their proven safe and effective DOC Band cran

54、ial orthotic.The DOC Band is the only device supported by clinical studies and over 35 years of documented outcomes.Each of the bands are custom made using state-of-the-art technology and lightweight,hypoallergenic materials that ensure safety and comfort.The corporate headquarters is located at Tem

55、pe Business Center II in Tempe.AZ.FOUNDED IN TEMPE IN 198695 GREATER PHOENIX EMPLOYEESGT Medical Technologies is a developer of a medical therapeutic technology designed to overcome the limitations of current treatments for recurrent brain tumors.The companys technology features a bioresorbable,conf

56、ormable,collagen tile and a uniform radiation source that offers advantages over the most common treatment for patients undergoing surgery for recurrent brain tumors,enabling medical practitioners to prevent disease progression and improve the quality of life for their patients.In 2024,GT Medical Te

57、chnologies acquired assets that make it the only manufacturer of Cesium-131 brachytherapy seeds for cancer treatments.FOUNDED IN TEMPE IN 201750 GREATER PHOENIX EMPLOYEESCardinal Health is a distributor of pharmaceuticals,a global manufacturer and distributor of medical and laboratory products,and a

58、 provider of performance and data solutions for healthcare facilities.They act as a crucial link between the clinical and operational sides of healthcare,delivering end to end solutions and data driving insights that advance healthcare and improve lives every day.LOCATED TO CHANDLER IN 2005140 GREAT

59、ER PHOENIX EMPLOYEES109Source:Maricopa Association of Governments&Company Websites.Regenesis is a device company dedicated to improving human welfare through the research,design,manufacture,and sale of energy-based medical products and services that alleviate pain to improve quality of life.The comp

60、any was founded in 1996 on a technology platform conceived and developed by Dr.Frank George and Dr.Mary Ritz.This technology,called Cell Proliferation Induction,offers non-drug pain management used for the palliative treatment of post-operative pain and edema of soft tissue,enabling doctors to cure

61、post-operative pain and edema in patients effectively.The corporate headquarters is located at Phase 5 of the Chaparral Business Center in Scottsdale,AZ.Its research lab is in the 850 PBC building.FOUNDED IN SCOTTSDALE IN 199680 GREATER PHOENIX EMPLOYEESRegional DemographicsRobust population growth

62、across Greater Phoenix is supported by strong net migration.The metros population has grown from 375,000 people in 1950 to more than five million residents today.Greater Phoenix added an estimated 55,120 residents in 2023,ranking the metro among the top five major U.S.metros in population growth for

63、 the year.Looking forward,Greater Phoenixs population is expected to grow at an average annual rate of 1.5 percent over the next eight years,more than double the national rate of growth.While Greater Phoenix initially made a name for itself as a retirement destination,the metro currently boasts a yo

64、ung population relative to the national median age,with a local median age of 37.4 years.In 2022,47 percent of in-migrants were between the prime working ages of 18 and 44.This young and growing skilled labor pool offers long-term stability to local employers.SAN FRANCISCODENVERLAS VEGASLOS ANGELESA

65、USTINDALLASPHOENIXSEATTLEUS AVERAGEATLANTASALT LAKE CITYMedian Age39.737.837.737.437.337.036.935.535.333.3111238.5U.S.PROJECTED AVERAGE ANNUAL GROWTH 2022-2030Population ProjectionsGREATER PHOENIX PROJECTED AVERAGE ANNUAL GROWTH 2022-20300.4%1.5%Between 2020 and 2023,Greater Phoenix netted the 3rd-h

66、ighest gain in population among all U.S.metros:almost 195,000 people.Source:American Community Survey(ACS)2018-2022 5 Year Estimates.Source:U.S.Census Bureau,Population Division,U.S.Census Metropolitan and Micropolitan Statistical Areas Totals:2020-2023.1413Source:US Census Bureau,2023.Number Of Peo

67、ple(Thousands)200020042002200620082011201420172020200120052003200720102013201620192009201220152018202120222023020804010060120140NET MIGRATIONNATURAL INCREASEHISTORICAL AVERAGEGreater Phoenix Robust Population Growth Driven By Net Migration14131516As of 2023,Greater Phoenix firms in the bioscience an

68、d life science industries employed over 26,600 people.This figure is the result of concerted regional cooperation dating back almost two decades between public,private and nonprofit stakeholders to establish the region as a destination market for the sector.Those plans have been paying off in earnes

69、t since the region fully shook off the effects of the Great Recession beginning around 2015,as several rates of growth exceed peer markets across the United States.Of the 40 U.S.metros with bioscience and life science employment of 10,000 jobs or more,Greater Phoenix had the fourth-highest growth ra

70、te in bioscience employment between 2015-23(66 percent),just ahead of Boston and behind San Francisco.During this timeframe,regional bioscience employment grew 2.5 times more than the national level.In keeping with its ascendance as a U.S.manufacturing hotspot,the region saw explosive employment inc

71、reases in Pharmaceutical and Medical Manufacturing once it emerged from the Great Recession,experiencing 147 percent growth between 2015-23 more than six times higher than the national average of 23 percent.This was led by the Medicinal and Botanical Manufacturing,In-Vitro Diagnostic Substance Manuf

72、acturing,and Biological Product(Except Diagnostic)Manufacturing industries.Likewise,Greater Phoenix distinguished itself in Medical Equipment and Supplies Manufacturing employment(such as surgical/medical instruments and equipment manufacturing),with jobs in these industries growing at 156 percent c

73、ompared to 14 percent nationally between 2015 and 2023.Regional bioscience and life science momentum extends beyond manufacturing.Greater Phoenix is gaining an edge in medical and diagnostic lab work,adding jobs and new businesses at more than double the national growth rate during this time span.Em

74、ployment increases at regional R&D firms,bolstered by specialties in biotechnology R&D and physical/engineering/life sciences R&D,paced ahead of national growth as well.Importantly for these two competitive,innovation-driven industries,Greater Phoenix has been a nexus of new biotech and life science

75、 R&D firm creation.While U.S.payrolled business locations in these industries doubled between 2015 and 2023,the number of such businesses in Greater Phoenix tripled.Industries&EmploymentSPECIALIZED WORKFORCEGreater Phoenix has around 6,000 resident workers in the skilled,knowledge-intensive occupati

76、ons required by the bioscience and life science industries.The number of resident workers with skilled bioscience/life science occupations in Greater Phoenix increased at over 1.5 times the average annual growth rate of the nation between 2015 and 2023(4.4 percent average annual growth versus 2.8 pe

77、rcent).Greater Phoenix saw robust 150 percent growth among Data Scientists,for example,and its gains in Life Scientist occupations outpaced the nation(25 percent versus 19 percent),with particularly strong upticks among Epidemiologists and Biochemists/Biophysicists relative to national trends.Encour

78、agingly for core work in the physical sciences,Greater Phoenix saw outsized growth among Chemists and managed to add Life/Physical/Social Science Technicians even as the nation lost them during this span.Greater Phoenix Specialized Bioscience Talent SupplyBIOENGINEERS&BIOMEDICAL ENGINEERSEPIDEMIOLOG

79、ISTSBIOLOGICAL SCIENTISTS(ALL OTHER)BIOLOGICAL TECHNICIANSCHEMISTSMEDICAL SCIENTISTSCHEMICAL TECHNICIANSEngineersLife ScientistsPhysical ScientistsLife,Physical,&Social Science Technicians214249297349480771819CHEMICAL ENGINEERSMICRO-BIOLOGISTSBIOCHEMISTS&BIOPHYSICISTSLIFE SCIENTISTS(ALL OTHER)979311

80、5156Mathematical Science OccupationsDATA SCIENTISTS2,3091718Each year,institutions in Greater Phoenix produce a growing number of graduates in local bioscience and life science programs.In the 2021-22 academic year,Greater Phoenix-based educational institutions saw more than 2,100 completions in spe

81、cialized bioscience degree fields such as bioengineering,immunology/pathology,genetics,and a range of biology subdisciplines;3,600 total completions were issued in the state of Arizona at degree levels ranging from certificates to doctorates.Between the academic years 2016-17 and 2021-22,completions

82、 in bioscience-related fields from Greater Phoenix-based institutions grew by 1.5 times,averaging 8.3 percent year-over-year growth.Talent produced by the regions bioscience pipeline is in fact even more numerous than this,due to completions at Arizona State Universitys(ASU)flourishing Digital Immer

83、sion programs(though remote,Arizona-based students are one out of every five Digital Immersion learners).ASUs remote bioscience completions increased by 12 times in this span,producing over 1,300 graduates in total.Widening the search to include bioscience,life science and healthcare fields,the annu

84、al crop of talent produced by non-distance programs in the region topped 11,400 in 2022 alone,a figure that places the region ahead of markets like Atlanta,San Diego and Seattle.Greater Phoenixs STEM talent pipeline has seen similar growth,with regional STEM completions increasing by 67 percent betw

85、een 2012 and 2022 versus 33 percent nationally.With its share of statewide,non-distance bioscience completions growing from 50 percent in 2016-17 to 58 percent in 2021-22,Greater Phoenix is becoming an increasingly important source of talent in Arizona.This is largely attributable to dynamic institu

86、tional development and investment over the past few decades.In addition to physician and research talent emerging from six existing local medical schools at the University of Arizona,Mayo Clinic,Creighton,Tufts University Downtown Phoenix,A.T.Still University Osteopathic Medical School,and Midwester

87、n University(and with plans for an ASU medical school announced in 2023),ASU operates a 350,000 square foot Biodesign Institute with 15 research centers.The university offers coursework and degrees in Biomedical Informatics and Diagnostics,Biology and Microbiology,and Applied Biological Sciences.Fur

88、ther,Maricopa Countys well-regarded community college network offers two relevant associate degrees:one in Science with an emphasis in Biological Sciences and another in Biotechnology and Molecular Biosciences.The Maricopa County Community College District has also developed pre-med and biology trac

89、ks that allow students to seamlessly transfer to ASU.Education&Talent PipelineASUS SCHOOL OF LIFE SCIENCES is shaping a future of innovation through a culture of collaborative research and connected education.Access to cutting-edge faculty labs and interdisciplinary centers and institutes empowers a

90、 new generation of leaders,giving them the resources and training they need to change lives.Biomedicine Microbiology Genetics,Cell and Developmental Biology Human Dimensions of Biology Molecular Biosciences and Biosciences TechnologyUNDERGRADUATE DEGREES INCLUDE:UNDERGRADUATE DEGREESMINORS AND CERTI

91、FICATESGRADUATE DEGREESRESEARCH CENTERS1061620RANKED#1 MOST INNOVATIVE UNIVERSITY NINE YEARS IN A ROWSTUDENTS ENROLLED IN SCHOOL OF LIFE SCIENCE COURSESUNDERGRAD AND GRADUATE STUDENTSIN ANNUAL RESEARCH EXPENDITURES#111,974145,655$797MSource:Arizona State University,Fall 2023.20 All Other Arizona Sch

92、ools Northern Arizona University Grand Canyon University University of Arizona ASU Campus Immersion ASU Digital ImmersionSource:Integrated Postsecondary Education Data System.2016-17COMPLETIONSACADEMIC YEAR5001.5K2.5K3.5K1K2K3K4K4.5K2017-182018-192019-202020-212021-22COMPLETIONS FROM AZ INSTITUTIONS

93、 IN BIO-SPECIFIC DISCIPLINES(INCLUDES FIRST AND SECOND MAJORS)19Between 2017-22,bio-specific completions at Greater Phoenix institutions averaged over 8%annual growth.COMPLETION TYPES Certificates Above The Baccalaureate Associates Degree Bachelors Degree Masters Degree Doctors Degree-Research/Schol

94、arship Doctors Degree-Professional Practice Doctors Degree-Other FIELDS Biomedical/Medical Engineering Biochemical Engineering Biological/Biosystems Engineering Biology General Biochemistry Biophysics and Molecular Biology Botany/Plant Biology Cell/Cellular Biology and Anatomical Sciences Microbiolo

95、gical Sciences and Immunology Zoology/Animal Biology Genetics Physiology Pathology and Related Sciences Pharmacology and Toxicology Biomathematics Bioinformatics and Computational Biology Biotechnology Ecology Evolution Systematics and Population Biology Molecular Medicine Neurobiology and Neuroscie

96、nces Biological and Biomedical Sciences Other Biological and Physical Sciences Biopsychology Human Biology Biology Technician/Biotechnology Laboratory Technician22As of Q1 2024,there is roughly 2.5 million square feet of existing life sciences space throughout Greater Phoenix.Just over 360,000 squar

97、e feet of this space remains available for lease entering April,amounting to a vacancy rate of 14.6 percent.One of the most notable projects in Greater Phoenix is the PBC.Home to tenants such as Calviri,the National Institutes of Health,Exact Sciences,Translational Genomics Research Institute and al

98、l three of Arizonas public research universities.The PBC is a 30-acre life sciences innovation district in the heart of Downtown Phoenix that serves as an integral piece of the statewide life sciences initiative as the faculty contributes significantly to biomedical discoveries,the quality of health

99、 care for Arizona residents and the expansion and diversification of the states economy.This hub currently has 1.7 million square feet of space dedicated to Research,Academic and Clinic facilities and has more than 6 million square feet of planned additions.Another significant area is the recently d

100、esignated Phoenix Medical Quarter in Midtown.The nucleus of this hub is located in Park Central,a former shopping destination that has now evolved into a dynamic center for bioscience,education and research.Organizations such as Creighton University School of Medicine,Phoenix Childrens Hospital,Bann

101、er Health,Dignity Health(home of the Norton Thoracic Institute)and Barrow Neurological Institute(home of the Ivy Brain Tumor Center)all occupy space within this bioscience corridor.There is also a large cluster of bioscience firms south of Sky Harbor Airport.This area houses tenants such as Caris Li

102、fe Sciences,GE Healthcare,Inform Diagnostics,Reference Medicine and Schott,with most of these firms occupying space in the Cotton Center Building Park.Meanwhile in North Phoenix,Mayo Clinic is planning an addition to its campus called Discovery Oasis.Covering an area of 218 acres which will include

103、wet and dry lab space,biomanufacturing facilities and flexible office space,this project will support intensified research,clinical expansion and the development of innovative clinical approaches to medicine and healthcare through the Mayo Clinic and ASU MedTech Accelerator.Emerging Bioscience Corri

104、dorsN2110114310120220260601017105134178526T E M P EM E S AS C O T T S D A L EG L E N D A L EP E O R I AS U N C I T YF O U N T A I N H I L L SP H O E N I XG I L B E R TC H A N D L E RMETRO PHOENIX DISTRICTS 1 2 34 5 6 7 8South Airport Caris Life Sciences GE Healthcare Inform DiagnosticsTempe ASU Bect

105、on DickinsonMayo Clinic Campus Discovery OasisDeer Valley Pinnacle Transplant TechnologiesSouthwest Phoenix Bristol Meyers SquibbWilliams Gateway/Loop 202 Cardinal HealthDowntown PhoenixPBC TGen Calviri NIH Exact Sciences ASU,UA,NAUMidtownPhoenix Medical Quarter Creighton School of Medicine Phoenix

106、Childrens Hospital Banner Health Dignity Health Barrow Neurological Institute WearTech CenterSource:CoStar,CBRE Research.2423N 5TH STE ROOSEVELT STE MCKINLEY STE PIERCE STN 6TH STE FILLMORE STE TAYLOR STE VAN BUREN STE MONROE ST7TH STN 7TH STN 5TH STN 3RD STN 3RD STN 2ND STN 2ND ST E POLK ST E POLK

107、STNotable College Campuses and Companies in the PBCPhoenix Bioscience CoreSource:City of Phoenix.ACADEMICRESEARCHCLINICALOFFICEFLEX SPACE850 N 5th St850 N 5th Street475 N 5th Street445 N 5th St425 N 5th St475 N 5th St425 N 5th Street445 N 5th Street2526Companies in the bioscience or life science ind

108、ustries will find a highly competitive operating cost environment in Greater Phoenix,in addition to the abundant talent working in the region and graduating from local institutions.The region distinguishes itself with skilled but affordable labor,reasonable utility costs,and a property tax system th

109、at has been structured to minimize the burden of doing business in Arizona.Operational Cost ComparisonTOPLINE ASSUMPTIONSOPERATING COSTSDETAILED WORKFORCE ASSUMPTIONSPERSONAL PROPERTY INVESTMENTELECTRIC:1,000KW/400,000KWH WATER:50,000CF,2 METER WASTEWATER:50,000CF,2 METERJOBSINDUSTRIAL MANUFACTURING

110、(LEASE)$25 MillionUtilities Per Month392250,000 SFOCCUPATIONSEMPLOYMENTMedical and Clinical Laboratory Technicians212Inspectors,Testers,Samplers,and Weighers55Laborers and Material Movers,Hand51Packers and Packagers,Hand51Shipping,Receiving,and Traffic Clerks6Biochemists and Biophysicists5General an

111、d Operations Managers5Biomedical Engineers3Logisticians2Industrial Production Managers1Human Resources Specialists1TOTAL392 METROEMPLOYEE PAYROLLFRINGE&MANDATED BENEFITSUTILITIESREAL ESTATE PAYMENTS*PROPERTY TAXTOTAL OPERATING COSTINDEXPHOENIX$22,705,800$5,181,732$506,759$2,700,000$11,496$31,105,787

112、 100.0%ATLANTA$23,352,714$5,508,269$549,110$2,152,500$399,700$31,962,293 102.8%BOSTON$27,468,811$6,417,355$2,415,733$3,362,500$617,000$40,281,399 129.5%HOUSTON$24,251,386$5,559,841$683,379$1,800,000$566,215$32,860,821 105.6%NASHVILLE$22,863,721$5,243,514$715,932$1,910,000$244,050$30,977,217 99.6%NEW

113、 YORK*$27,422,393$6,758,897$1,064,192$4,370,000$0$39,615,482 127.4%RALEIGH$22,760,108$5,339,925$481,197$2,400,000$253,125$31,234,355 100.4%SAN DIEGO$26,544,121$7,608,153$1,903,601$4,170,000$293,500$40,519,375 130.3%SAN FRANCISCO$31,578,620$9,041,354$1,328,897$6,990,000$465,000$49,403,871 158.8%Sourc

114、e:Applied Economics Metrocomp Tool,January 2024.*The leasing term includes real property tax.*There is no personal property tax in New York.As more startups and tech companies are deciding to set up their operations in the state,Arizona has seen a jump in life sciences interest.Since 2019 there have

115、 been 88 deals accounting for roughly$623.3 million in venture capital funding.Although VC funding took a dip in 2022,the amount of investment in 2023 rebounded substantially,as bioscience companies raised$195.9 million during the year.This growth trend highlights the thriving ecosystem of quality b

116、ioscience startups in the state of Arizona.The state has launched early key initiatives such as AZAdvances,a program that works with Arizona researchers and early-stage companies to develop discoveries and advance health innovations by providing entrepreneurial support and seed funding that is neede

117、d to accelerate the process.Resources providing support on the path to commercialization,coupled with the states rapidly growing population and talent pool,make Arizona a desirable location for innovators and entrepreneurs.Venture Capital FundingCOMPANIES13COMPANIES18COMPANIES19COMPANIES20COMPANIES1

118、8Total FundingTotal Funding2728The Arizona life sciences industry has reached new heights over the past several years.Source:PitchBook Data,Inc.,2024(Pharmaceuticals and Biotechnology and Healthcare Devices and Supplies Industry Groups).$119.3 MILLION2019$80.8 MILLION2020$131.6 MILLION2021$95.7 MILL

119、ION2022$195.9 MILLION20233029Xcellerant Ventures is among the newest VC firms in ArizonaIt focuses on early stage HealthTech,MedTech and TechBio startups40%of its portfolio is from Arizona29Source:PitchBook Data,Inc.2024.in total life sciences venture capital funding,comprising 88 Arizona companies

120、over the past five years.In 2023,Greater Phoenix placed$623.3 Million41stin a PitchBook ranking of global VC ecosystemsArizona Venture Capital Funding“We are seeing a tremendous opportunity to invest early in scalable companies in the local Healthcare and Life Sciences industry,a fact that reflects

121、both the quality and the quantity of innovative startups originating from local research institutions as well as seasoned entrepreneurs attracted to the regions emerging ecosystem.The fact that 40 percent of our portfolio is from Arizona indicates the rapid maturation of the ecosystem into increasin

122、gly viable,innovation-driven startups in our industry vertical.While 2010 was a high year for investments,we believe the totality of investments in 2023 has been in more companies that have more experienced entrepreneurs at the helm with significantly better chances of producing superior returns on

123、invested capital.Moreover,high-skilled jobs created by these growing startups is decelerating the emigration of locally educated talent,and accelerating the immigration of new economy workers who bring diverse background and cross-industry skillsets.Finally,the fact that a majority of our LPs are fr

124、om Arizona also indicates an increasingly sophisticated investor base that is investing in Healthcare and Life Sciences,a key ingredient for a sustainable growing industry.Chris Yoo,Ph.D.General Partner Xcellerant Ventures31Arizona Venture Capital Funding Spotlight 2019-2023$71M$36.6M$25.9M$20.1M$16

125、.1M$26.5M$24.6M$18.9M$15.1M$15MArizona Venture Capital by Funding Type 2019202332Therapeutic Devices|$148.6 MILLIONPharmaceuticals|$142.5 MILLIONBiotechnology|$96.4 MILLIONDiagnostic Equipment|$81.5 MILLIONDrug Discovery|$54.4 MILLIONOther Devices&Supplies|$37.3 MILLIONOther Pharmaceuticals&Biotechn

126、ology|$20.5 MILLIONMonitoring Equipment|$20.0 MILLIONSource:PitchBook Data,Inc.,2024(Pharmaceuticals and Biotechnology and Healthcare Devices and Supplies Industry Groups).Source:PitchBook,2024.Data from 2019-2023.Subsidiary of Fortress Biotech,Inc.Aquired by Exact Sciences in 2020Drug Delivery|$12.

127、6 MILLIONSurgical Devices|$6.1 MILLIONMedical Supplies|$3.0 MILLIONDiscovery Tools(Healthcare)|$400,00034The state of Arizona has also seen a notable rise in funding from the National Institutes of Health(NIH)for medical research.The amount of NIH funding has improved each year since 2019,reaching$3

128、64.2 million in 2023,ranking Arizona 25th among all US states.Additionally,this marks a nearly 39 percent increase in funding relative to 2019,which is a testament to the robust growth in Arizonas healthcare and biosciences sectors during this time frame.Among the 198 institutions receiving NIH fund

129、ing in Arizona since 2019,the University of Arizona was the top recipient,with$846.7 million in awards.Arizona State University ranked second in the state with$289.5 million in NIH awards.With all three of Arizonas public universities pouring additional resources into healthcare and biosciences,it i

130、s likely NIH funding for local institutions will continue to rise in the coming years as these sectors continue to grow across the state.National Institutes of Health FundingSource:PitchBook Data,Inc.2024.$262,962$282,446$346,328$364,156$311,52820192020202120222023TOP NIH FUNDED INSTITUTIONS IN ARIZ

131、ONA(2019-2023)$846.7 MILLION$289.5 MILLION$86.4 MILLION$64.1 MILLION$59.8 MILLION$59.5 MILLION$25.2 MILLION$10.4 MILLION$7.9 MILLION$5.9 MILLIONTotal NIH Fundingin Thousands333536Although NIH funding in Greater Phoenix has not yet reached the levels of other primary bioscience markets,the metro rank

132、s first in NIH funding growth over the past five years among all markets with at least$100 million in annual funding in 2022,recording an increase of more than 80 percent during this time frame.Greater Phoenix also ranks among the top 10 markets in NIH funding growth over the past 10 years.These fig

133、ures highlight the metros strong momentum in the biosciences industry.Growth and Momentum in NIH Funding Among Major U.S.MarketsSan AntonioSan DiegoKansas CityHoustonMinneapolis-St.PaulSt.LouisLos Angeles-Orange CountyDenver-BoulderAtlantaDallas-Ft.WorthRaleigh-DurhamIndianapolisNew York-New JerseyS

134、eattleNew HavenSalt Lake CitySan Francisco Bay AreaCincinnatiNashvillePortlandPittsburghPhiladelphiaMiami-Fort LauderdaleSacramentoAustinClevelandTampaRichmondBoston-CambridgeWashington DC-BaltimoreSource:National Institutes of Health,CBRE Research,Q4 2023.Note:Major markets with more than$100 milli

135、on in annual NIH Funding in 2022.0%0%30%70%10%40%80%20%60%50%90%20%40%60%80%100%120%10-YEAR CHANGE IN NIH FUNDING(2012-2022)U.S.5-YEAR GROWTH(41%)U.S.10-YEAR GROWTH(56%)5-YEAR CHANGE IN NIH FUNDING(2017-2022)Markets with faster NIH funding growth over the last 5 and 10 years.Markets with slower rece

136、nt NIH funding growth but faster over the last 10 years.Markets with slower NIH funding growth over the last 5 and 10 years.Markets with faster recent NIH funding growth but slower over the last 10 years.Chicago35Phoenix37The federal governments Small Business Innovation Research(SBIR)and Small Busi

137、ness Technology Transfer(STTR)programs offer competitive grants that provide capital,institutional research partnerships,and pathways to commercialization for the nations small businesses and startups working at the leading edge of technology.SBIR/STTR funding to Greater Phoenix businesses developin

138、g bioscience technology has grown tremendously in the past decade,increasing from$2.7M to$10.2M between 2012 and 2022(the latest year with complete data)a growth rate of 277 percent,compared to a 21 percent growth rate nationally.Grant dollars to Greater Phoenix bioscience startups experienced 25 pe

139、rcent median year-over-year growth in this span,compared to 10 percent for Arizona and five percent for the nation.The regions and states firms have distinguished themselves as increasingly competitive in the past half-decade,even as SBIR/STTR funding to bioscience firms nationwide has been decreasi

140、ng since 2020.Local bioscience startups that secured SBIR/STTR funding recently on their journey to commercialization include Calviri(2019)and CND Life Sciences(2020&2022).Small Business Technology Transfers and Funding654321020122013201420152016USAZGREATER PHOENIX201720182019202020212022Growth of S

141、BIR-STTR Bioscience Funding Indexed to 2012Funding to Greater Phoenix businesses developing bioscience technology has increased from$2.7M to$10.2M between 2012 and 2022.38$10.2 MILLIONFunding in 2022$2.7 MILLIONFunding in 2012Source:U.S.Small Business Administration,Small Business Innovation Researc

142、h(SBIR).40When CND Life Sciences in Scottsdale,Arizona developed a first-of-its-kind skin test to detect diseases like Parkinsons or dementia,its diagnostic required clinical validation.Immediately after initial trials,the cutaneous neurodiagnostic test detecting notable biomarkers was adopted by bo

143、th Mayo Clinic and Banner Health,resulting in an increased cohort of participants,and therefore more data for CND Life Sciences to further refine the diagnostic.39Regional Case StudyRegional Healthcare Assets&Clinical TrialsGreater Phoenix has an expansive and mature healthcare ecosystem,whose world

144、-class providers announced over$4B in capital investments between 2019 and 2023.Local healthcare providers Banner Health,HonorHealth,Dignity Health,and Mayo Clinic are four out of the 10 largest private sector employers in Greater Phoenix.The regions hospitals,institutions,and firms participate as s

145、ponsors or collaborators in an average of nearly 600 clinical trials annually registered with the National Institutes of Health.Regional standouts in translational research include the City of Hope and Mayo Clinic in oncology and precision/regenerative medicines.In the field of neurology,the Barrow

146、Neurological Institute was recently chosen as the inaugural site for Elon Musks Neuralink PRIME study,and its Ivy Brain Tumor Center announced promising findings from a trial studying the effects of kinase inhibitors on newly diagnosed glioblastoma.A network of research-oriented regional healthcare

147、assets is important to the development of a closed-loop bioscience ecosystem.Many medtech and bioscience firms,from startups to well-established incumbents,need access to healthcare partners that are actively running clinical trials to validate and test their products or technologies.Positive proof-

148、of-concept clinical trials open the gateway to commercialization and expedite go-to-market time.Eventually,healthcare assets like large hospital systems become the bioscience companies recurring customers,a fact which underscores the importance of in-market access to clinical research and trial acti

149、vity that can support and complement bioscience technology development in a metro region.AuthorsKEVIN CARRANZASenior Director,Business Intelligence Greater Phoenix Economic CouncilCARLOS PIETRISenior Field Research Analyst CBREDesignREBECCA LATHAMSenior Graphic Designer CBREReport CreditsContactsCHRIS CAMACHOPresident&CEO Greater Phoenix Economic Council+1 602 262 8603 cpcamachogpec.orgCATHY TEETERManaging Director CBRE+1 602 735 5603 ALLISON BAKOVICVice President,Bioscience Business Development Greater Phoenix Economic Council+1 602 262 8617 abakovicgpec.org